Concepedia
Biochemical and Biophysical Research Communications · 2011 · 91 citations · 20 references
Medicinal ChemistryBiochemistryAntineoplastic EffectNatural SciencesMedicineOct1 TransporterOrganic ChemistryToxicologyChemistryChemical BiologyPharmacology
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The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin
Reuben J. Shaw, Katja Lamia, Debbie S. Vasquez et al. · Science · 2005 · 1.9K citations
Ampk Activity, Therapeutic Effects, Metabolic Remodeling +21
Dimethylbiguanide Inhibits Cell Respiration via an Indirect Effect Targeted on the Respiratory Chain Complex I
Mohamad-Yehia El-Mir, Véronique Nogueira, Éric Fontaine et al. · Journal of Biological Chemistry · 2000 · 1.4K citations · Full text
Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action
Yan Shu, Steven A. Sheardown, Chaline Brown et al. · Journal of Clinical Investigation · 2007 · 942 citations · Full text
Metformin Action, Molecular Biology, Cellular Physiology +20
Metformin Inhibits Mammalian Target of Rapamycin–Dependent Translation Initiation in Breast Cancer Cells
Ryan J.O. Dowling, Mahvash Zakikhani, I. George Fantus et al. · Cancer Research · 2007 · 923 citations · Full text
Important role of the LKB1–AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice
Xu Huang, Stephan Wullschleger, Natalia Shpiro et al. · Biochemical Journal · 2008 · 390 citations · Full text