Organic Letters · 2014 · 42 citations · 12 references
PharmacyMarine BiologyMedicinal ChemistryAntimicrobial PharmacologyDrug DiscoveryStructure-activity RelationshipsMarine Bioactive CompoundsMarine Natural ProductsStructure-activity Relationship AnalysisBioactive Compounds From Marine SpongesBioactive Marine MetabolitesMarine AlkaloidsMarine Sponge MetabolitesPlant AlkaloidsSponge SystematicsSponges As Drug SourcesSponges-derived Metabolites
Two structurally unique dimeric bromopyrrole alkaloids, agelamadins A (1) and B (2), were isolated from a marine sponge Agelas sp. Agelamadins A (1) and B (2) have a structure consisting of an agelastatin-like tetracyclic moiety and an oroidin-like linear moiety in common. The structures of 1 and 2 were elucidated on the basis of spectroscopic analysis. The antimicrobial activity and cytotoxicity of agelamadins A (1) and B (2) were evaluated.
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Michele D’Ambrosio, Antonio Guerriero, Olivier Ribes et al. · Journal of the Chemical Society Chemical Communications · 1993 · 152 citations