The characterization and release kinetics evaluation of baclofen microspheres designed for intrathecal injection

Mechanism of sustained‐action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices

Tsunehiko Higuchi · Journal of Pharmaceutical Sciences · 1963 · 4.8K citations

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Intrathecal baclofen for spasticity of spinal origin: seven years of experience

Richard D. Penn · Journal of neurosurgery · 1992 · 284 citations

Medicine, Neurosurgery, Pharmacotherapy +15

Controlled release: mechanisms and release.

Baker Rw, Lonsdale Hk · 1974 · 217 citations

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Biodegradation and brain tissue reaction to poly(D,L-lactide-co-glycolide) microspheres

Philippe Meneï, Valérie Daniel, Claudia N. Montero‐Menei et al. · Biomaterials · 1993 · 181 citations

Natural Sciences, Bioengineering, Biomedical Engineering +12

Continuous infusion of intrathecal baclofen: long-term effects on spasticity in spinal cord injury

Paul G. Loubser, Raj K. Narayan, Karl J. Sandin et al. · Spinal Cord · 1991 · 146 citations

Medicine, Neurology, Neurosurgery +17