Zn[(L)proline]₂: An Efficient Catalyst for the Synthesis of Biologically Active Pyrano[2,3-<i>d</i>]pyrimidine Derivatives

Abstract

Biologically active pyrano[2,3-d]pyrimidine derivatives were efficiently synthesized in excellent yields by a three-component, one-pot condensation reaction of malononitrile, benzaldehydes, and barbituric acid using a catalytic amount of Zn[(L)proline].