IEEE/ACM Transactions on Computational Biology and Bioinformatics · 2012 · 157 citations · 31 references
PharmacyBioinformaticsInfectious DiseasesDrug DesignDrug DiscoveryMachine LearningAntimicrobial PeptidesComputational Drug DiscoveryPeptide Drug DiscoveryPeptide IdentificationSupport Vector MachinesAntibacterial PeptidesAntifungal PeptidesAntimicrobial Peptide ActivityAntiviral PeptidesMachine Learning Scoring ModelsPeptide Sequence SearchPeptide Structure-activity RelationshipsRandom Forests
Antimicrobial peptides (AMPs) are gaining popularity as anti-infective agents. Information on sequence features that contribute to target specificity of AMPs will aid in accelerating drug discovery programs involving them. In this study, an algorithm called ClassAMP using Random Forests (RFs) and Support Vector Machines (SVMs) has been developed to predict the propensity of a protein sequence to have antibacterial, antifungal, or antiviral activity. ClassAMP is available at http://www.bicnirrh.res.in/classamp/.
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R: A Language and Environment for Statistical Computing
R Core Team · 2000 · 353K citations · Full text
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Andy Liaw, Matthew C. Wiener · 2007 · 18.4K citations
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Isabelle Guyon, Jason Weston, S. Barnhill et al. · Machine Learning · 2002 · 9.8K citations · Full text