Chemical Communications · 2011 · 22 citations · 12 references
MedicineMedicinal ChemistryPharmacologyBiochemical PharmacologyCancer PharmacologyDrug DiscoveryAlkaloid BiosynthesisApoptosis PharmacologyHeterocyclic ChemistryMarine Bioactive CompoundsMarine Drug DiscoveryMarine PharmacologyAnticancer Marine CompoundsBioactive Compounds From Marine SpongesMarine AlkaloidsMarine Sponge MetabolitesMarine Sponge Natural Product BiosynthesisMarine-derived Anticancer CompoundsPlant AlkaloidsSponges As Drug Sources
Novel sesquiterpene alkaloids, halichonines A (1), B (2), and C (3), were identified from the marine sponge Halichondria okadai Kadota. By spectroscopic analyses and synthesis, their structures were revealed to include a 6,6-bicyclic ring system and two prenylated amine moieties. In addition, 2 induced apoptosis in HL60 human leukemia cells.
12
Ahmed F. Abdel‐Magid, Kenneth G. Carson, Bruce D. Harris et al. · The Journal of Organic Chemistry · 1996 · 1.5K citations