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Facile synthesis of disubstituted and spiro five-membered benzosultams mediated by TMSCl–NaI–MeCN reagent
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Citations
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References
2002
Year
High YieldsCombinatorial ChemistryDiversity Oriented SynthesisEngineeringHeterocyclicTmscl–nai–mecn ReagentFacile SynthesisDiversity-oriented SynthesisNatural SciencesOrganic ChemistrySpiro Five-membered BenzosultamsCarbinol SulfonamidesChemistryHeterocycle ChemistryPharmacologySynthetic ChemistryBiomolecular EngineeringUnderwent Tmscl–nai–mecn Reagent
o-Lithiation of N-tert-butylbenzenesulfonamide followed by reaction with ketones gave carbinol sulfonamides, which underwent TMSCl–NaI–MeCN reagent mediated cyclization to afford 3,3-disubstituted and spiro-2,3-dihydrobenzo[d]isothiazole-1,1-diones in high yields.
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