Head & Neck · 2001 · 71 citations · 11 references
MedicineOncologyRadiation OncologyChemotherapyDysphagiaSwallowing RehabilitationClinical Swallowing EvaluationConcurrent ChemoradiationInstrumental Swallowing AssessmentRadiation TherapySwallowing AssessmentVideofluoroscopic Swallow StudyArticulationConcurrent Chemoradiation TherapyHead And Neck Cancer-related DysphagiaIonizing IrradiationIrradiation EffectsRadiation-associated DysphagiaRadiation-induced DysphagiaVideofluoroscopic Swallowing Analysis
OBJECTIVE: RADPLAT (concurrent selective supradose intraarterial cisplatin and external-beam irradiation) delivers extraordinarily high cisplatin concentration to head and neck structures. This study was designed to quantify and compare RADPLAT and systemic chemoradiation treatment effects on swallowing and speech. METHODS: Videofluorographic swallowing studies and articulation testing of 14 head and neck cancer patients treated with RADPLAT were compared with 16 treated with systemic chemoradiation 1 month after treatment. RESULTS: RADPLAT and systemic chemoradiation patients did not differ significantly on most swallow outcome measures, and there was significantly less aspiration on 1 and 3 mL liquid for RADPLAT individuals. Speech function was comparable except for RADPLAT's significantly worse /s, z/ productions. CONCLUSIONS: Increased concentration of cisplatin to the head and neck did not result in generally reduced swallowing or articulatory function.
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Targeted chemoradiation for advanced head and neck cancer: Analysis of 213 patients
K. Thomas Robbins, Parves Kumar, Frank S. H. Wong et al. · Head & Neck · 2000 · 213 citations