Endocrinology · 1944 · 40 citations · 0 references
MedicineBiochemistryEndocrinologyEndocrine OncologyProstate DiseaseSteroid BiochemistryAdrenal TumorsBenign Prostatic HyperplasiaEndocrine TumorsProstate CancerProstatic PathologyAdrenal Cortical HyperplasiaUrinary Steroid Analysis
LITTLE is known about the ratios of urinary alpha and beta1 17- ketosteroids in normal and diseased states (Baumann and Metzger, 1940; Talbot and his coworkers, 1942; Rhoads, Dobriner and their collaborators, 1942b; Conference on Ketosteroids, 1942). That such determinations may be of clinical importance is suggested by the reports that relatively large amounts of the beta form are present in cases of adrenal cortical carcinoma (Crooke and Callow, 1939; Talbot and his coworkers, 1942). Scott and Vermeulen (1942) have reported a difference in the relative amounts of alpha and beta fractions in patients with prostatic carcinoma before and after castration. The different workers have based their separation into alpha and beta ketosteroid fractions on the observation that steroids present in the beta fraction are precipitated by digitonin, but different procedures have been followed so that the results are not comparable.