Isolation of 1-Methyl-1,2,3,4-Tetrahydroisoquinoline-Synthesizing Enzyme from Rat Brain: A Possible Parkinson's Disease-Preventing Enzyme

Mapping of a Gene for Parkinson's Disease to Chromosome 4q21-q23

Mihael H. Polymeropoulos, Joseph Higgins, Lawrence I. Golbe et al. · Science · 1996 · 777 citations · Full text

Localization of a gene for an autosomal recessive form of juvenile Parkinsonism to chromosome 6q25.2-27.

Hiroto Matsumine, Masaaki Saito, Satoe Shimoda‐Matsubayashi et al. · PubMed · 1997 · 374 citations

Increase of deleted mitochondrial DNA in the striatum in Parkinson's disease and senescence

Shin-ichiro Ikebe, Masashi Tanaka, Kinji Ohno et al. · Biochemical and Biophysical Research Communications · 1990 · 345 citations

Mitophagy, Mitochondrial Function, Genetics +6

An endogenous substance of the brain, tetrahydroisoquinoline, produces parkinsonism in primates with decreased dopamine, tyrosine hydroxylase and biopterin in the nigrostriatal regions

Toshiharu Nagatsu, Mitsuo Yoshida · Neuroscience Letters · 1988 · 198 citations

Tyrosine Hydroxylase, Neurophysiology, Neuroanatomy +13

Presence of tetrahydroisoquinoline and 2-methyl-tetrahydroquinoline in Parkinsonian and normal human brains

Toshimitsu Niwa, Naohito Takeda, Norio Kaneda et al. · Biochemical and Biophysical Research Communications · 1987 · 185 citations

Neurophysiology, Medicine, Neuropharmacology +10