Double-strand RNA dependent protein kinase (PKR) is involved in the extrastriatal degeneration in Parkinson's disease and Huntington's disease

Parkin Suppresses Unfolded Protein Stress-induced Cell Death through Its E3 Ubiquitin-protein Ligase Activity

Yuzuru Imai, Mariko Soda, Ryōsuke Takahashi · Journal of Biological Chemistry · 2000 · 771 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Deficient signaling in mice devoid of double‐stranded RNA‐dependent protein kinase.

Y. Yang, Luiz F. L. Reis, Jovan Pavlovic et al. · The EMBO Journal · 1995 · 632 citations · Full text

Life Sciences, Genetics, Molecular Biology +9

The Endoplasmic Reticulum Stress-Responsive Protein GRP78 Protects Neurons Against Excitotoxicity and Apoptosis: Suppression of Oxidative Stress and Stabilization of Calcium Homeostasis

ZaiFang Yu, Hong Luo, Weiming Fu et al. · Experimental Neurology · 1999 · 440 citations

Life Sciences, Biochemistry, Neuroscience +14

Phosphorylation of Eukaryotic Translation Initiation Factor 2 Mediates Apoptosis in Response to Activation of the Double-stranded RNA-dependent Protein Kinase

Sri Prakash Srivastava, Kotlo U. Kumar, Randal J. Kaufman · Journal of Biological Chemistry · 1998 · 382 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Activation of the dsRNA‐dependent protein kinase, PKR, induces apoptosis through FADD‐mediated death signaling

Siddharth Balachandran, Caryn N. Kim, Wen‐Chen Yeh et al. · The EMBO Journal · 1998 · 353 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +12