Acta Medica Scandinavica · 1968 · 44 citations · 17 references
PharmacyPharmacologyPharmacotherapyCardiovascular PharmacotherapyMineral MetabolismRenal PharmacotherapyBlood Pressure ManagementDiuretic TherapyHypertension ControlHypertension ManagementHypertension PharmacotherapyHypertensive DisordersAntihypertensive Drug TherapyAntihypertensive PharmacologyAntihypertensive TreatmentBlood PressureExchangeable Sodium EffectsExchangeable Sodium EstimationExchangeable Sodium MeasurementHypertensive Drug Response
Abstract Eleven patients with essential hypertension were treated with hydrochlorothiazide/KCl for three months. A significant fall in total blood volume, exchangeable sodium and blood pressure could be demonstrated both after one to two weeks and after three months of treatment, while a fall in serum sodium and body weight was only significant after one to two weeks of treatment. Thus, hypovolemia may, perhaps, be the explanation for the antipressor effect of thiazide even after three months of treatment.
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Hemodynamic and Hypotensive Effects of Long-term Therapy with Chlorothiazide
James Conway, P Lauwers · Circulation · 1960 · 255 citations · Full text
The "specialty" of general practitioner obstetrics.