Dioscin, a natural steroid saponin, shows remarkable protective effect against acetaminophen-induced liver damage in vitro and in vivo

ACETAMINOPHEN-INDUCED HEPATIC NECROSIS. I. ROLE OF DRUG METABOLISM

John R. Mitchell, David J. Jollow, William Z. Potter et al. · Journal of Pharmacology and Experimental Therapeutics · 1973 · 1.5K citations

N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen.

David C. Dahlin, Gerald T. Miwa, Albert Lu et al. · Proceedings of the National Academy of Sciences · 1984 · 1.1K citations

Pharmacotherapy, Redox Biology, Pharmaceutical Chemistry +21

Mitochondrial permeability transition in acetaminophen-induced necrosis and apoptosis of cultured mouse hepatocytes

Kazuyoshi Kon, Jae‐Sung Kim, Hartmut Jaeschke et al. · Hepatology · 2004 · 491 citations · Full text

Activation of Autophagy Protects Against Acetaminophen–Induced Hepatotoxicity

Hong‐Min Ni, Abigail Bockus, Nikki Boggess et al. · Hepatology · 2011 · 423 citations · Full text

The toxicity of acetaminophen and N-acetyl-p-benzoquinone imine in isolated hepatocytes is associated with thiol depletion and increased cytosolic Ca2+.

Matthew D. Moore, Hjördis Thor, Gregory Moore et al. · Journal of Biological Chemistry · 1985 · 411 citations · Full text

Ca2+ Homeostasis, Cell Death, Cytosolic Ca2+ +22