Impaired T‐Amplitude Adaptation to Heart Rate Characterizes I_Kr Inhibition in the Congenital and Acquired Forms of the Long QT Syndrome

Abstract

Impaired adaptation of T-amplitude to changing HR is a common electrocardiographic feature associated with KCNH2 mutation and I(kr) blockade by sotalol. This ECG marker may play an important role in the future of the assessment of the penetrance of KCNH2 mutation and the identification of a drug effect on the I(kr) kinetics.