Controlled Submolecular Translational Motion in Synthesis: A Mechanically Interlocking Auxiliary

Abstract

Sew simple: How can you put a molecular bead on a thread when no recognition elements exist between them? A mechanically interlocking auxiliary assembles the macrocycle around a template, controlled submolecular translation moves the ring over the desired substrate and, finally, cleavage of the auxiliary leaves an apparently “impossible” rotaxane (see scheme).