Enantioselective β-Replacement Reaction Mediated by an Artificial Enzyme Composed of a Hydrophobia Vitamin B6, Chiral Bilayer-forming Lipids, and Copper(II) Ions

Abstract

Abstract A hybrid bilayer membrane, composed of a synthetic lipid having an (S)-alanine residue, one having (S)-binaphthol and (S)-alanine moieties, a hydrophobic pyndoxal derivative, and copper(II) ions, exhibited a tryptophan synthase-like reactivity that affords tryptophan from serine and indole in an enantiomeric excess of the (S)-isomer.