Leukocyte Transfusions in Chronic Granulomatous Disease

Abstract

CHRONIC granulomatous disease of childhood is an inherited disease in which phagocytes lack the ability to use molecular oxygen to generate microbicidal oxygen byproducts (hydrogen peroxide, hydroxyl radical, or Superoxide anion). Classically recognized by the inability of their blood leukocytes to reduce the yellow dye nitroblue tetrazolium to blue-purple formazan, patients with this disease have recurrent serious infections caused by both bacterial and fungal pathogens.In this article we report our experience with white-cell transfusions given to a patient with chronic granulomatous disease who had life-threatening mixed fungal and bacterial pneumonia. The transfused cells cleared rapidly (within three hours) from . . .