HIYODORILACTONES A AND B, NEW TUMOR INHIBITORY GERMACRADIENOLIDES FROM <i>EUPATORIUM SACHALINENSE</i> MAKINO

Abstract

Abstract Three new sesquiterpene lactones belonging to the class of [1(10)E,4Z]-germacra-1(10),4-dienolide have been isolated from the leaves of Eupatorium sachalinense Makino, two of them (hiyodorilactones A and B) were found to show significant inhibitory activity in vivo against the Ehrlich ascites carcinoma. The structures of hiyodorilactones A, B, and C have been established to be 1, 2, and 3, respectively.