Mechanistic Model of the Elongation Complex of Escherichia coli RNA Polymerase

Abstract

RNA polymerase (RNAP) is the central enzyme ofgene expression and the focus of genetic regulation. Tounderstand regulation in molecular detail, one needs torelate the few RNAP basic functions to a myriad of influences that affect its activity. In other words, RNAP can beviewed as a core molecular machine that is target to regulatory signals...