Concepedia

Dissecting the Behavior of a Promiscuous Solvate Former

Christopher P. Price, Gary D. Glick, Adam J. Matzger

Angewandte Chemie International Edition · 2006 · 89 citations · 21 references

DOI

Concepts

Abstract

Take any partner: Benzodiazepine derivative Bz-423 (see picture) can be described as an indiscriminate solvate former as it cocrystallizes with a diverse array of small molecules. This behavior was investigated by analysis of the packing efficiency of these crystal forms relative to that of unsolvated Bz-423 and an appropriate model compound.

References

21

Comprehensive supramolecular chemistry

Choice Reviews Online · 1997 · 6.5K citations

, , +16

Crystal Engineering of Novel Cocrystals of a Triazole Drug with 1,4-Dicarboxylic Acids

Julius F. Remenar, Sherry L. Morissette, Matthew L. Peterson et al. · Journal of the American Chemical Society · 2003 · 681 citations

, , +17

Pharmaceutical Cocrystallization:  Engineering a Remedy for Caffeine Hydration

A.V. Trask, W. D. Samuel Motherwell, William Jones · Crystal Growth & Design · 2005 · 650 citations

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Crystal Engineering Approach To Forming Cocrystals of Amine Hydrochlorides with Organic Acids. Molecular Complexes of Fluoxetine Hydrochloride with Benzoic, Succinic, and Fumaric Acids

S.L. Childs, Leonard J. Chyall, J.T. Dunlap et al. · Journal of the American Chemical Society · 2004 · 630 citations · Full text

, , +14

Crystal Engineering of the Composition of Pharmaceutical Phases:  Multiple-Component Crystalline Solids Involving Carbamazepine

Scott G. Fleischman, S.S. Kuduva, Jennifer A. McMahon et al. · Crystal Growth & Design · 2003 · 532 citations

, , +15