Changes in the Oxidant-Antioxidant Balance in the Kidney of Rats With Nephrolithiasis Induced by Ethylene Glycol

Abstract

The possible mechanism that causes free radical elevation in the kidney may be different in the course of nephrolithiasis after ethylene glycol treatment. Initially the systemic circulation may bring the toxic substance into the kidney and cause it to produce free radicals. In the late stage gradually infiltrating leukocytes and decreased antioxidant enzyme activities may cause the kidney to remain under excessive oxidative stress.