Preferential Crystallization of a Helicene–Viologen Hybrid – An Efficient Method to Resolve [5]Helquat Enantiomers on a 20 g Scale

Abstract

Abstract The bistriflate salt of racemic [5]helquat 1 was found to form a conglomerate. Based on this finding, the preferential crystallization of this chiral helicene–viologen hybrid was developed to deliver pure enantiomers on a 20 g scale (10.5 g of each enantiomer). To the best of our knowledge, this is the largest amount of nonracemic helicene‐like compound obtained by preferential crystallization to date. The absolute configuration of the P enantiomer was confirmed by X‐ray crystal structure analysis. The chromatography‐free synthesis of racemic 1 on a multigram scale (30 g) is also presented as an entry point to this resolution study.