Episodic Binge Ethanol Exposure Impairs Murine Macrophage Infiltration and Delays Wound Closure by Promoting Defects in Early Innate Immune Responses

Abstract

These findings suggest that EtOH exposure hinders several distinct components of the innate immune response, including phagocyte recruitment and chemokine/cytokine and AMP production. Together, these effects likely contribute to delayed wound closure and enhanced infection severity observed in intoxicated patients.