Association between Chromosome 1p and 19q Loss and Outcome in Pediatric Malignant Gliomas: Results from the CCG-945 Cohort

Abstract

In contrast to recent observations of adult malignant gliomas, deletions involving chromosomes 1p or 19q did not predict a survival advantage in this series of pediatric high-grade gliomas, which might indicate that frequencies of various histologic and molecular subtypes of malignant gliomas differ between children and adults, and supports further efforts to identify prognostic indicators relevant to pediatric gliomas.