Early Pituitary-Gonadal Activation before Clinical Signs of Puberty in 5- to 8-Year-Old Adopted Girls: A Study of 99 Foreign Adopted Girls and 93 Controls

Abstract

Five- to 8-yr-old adopted girls showed signs of increased pituitary as well as gonadal activity despite prepubertal phenotype in the majority of girls. Our findings suggest that early onset of puberty in adopted girls is centrally driven.