Concepedia

A Highly Specific BODIPY-Based Fluorescent Probe for the Detection of Hypochlorous Acid

Fengqin Liu, Yan Chen, Paul Kwong Hang Tam, Dan Yang

Organic Letters · 2008 · 335 citations · 14 references

DOI

Concepts

Abstract

A fluorescent probe, HKOCl-1, has been successfully developed for the detection of hypochlorous acid on the basis of a specific reaction with p-methoxyphenol. The formation of HOCl has been successfully detected not only in an abiotic system but also in an enzymatic system (myeloperoxidase/H2O2/Cl(-) system) and in living macrophage cells upon stimulation. This new probe might be used as an efficient tool for probing the roles HOCl plays in biological systems.

References

14

The Chemistry of Fluorescent Bodipy Dyes: Versatility Unsurpassed

Gilles Ulrich, Raymond Ziessel, Anthony Harriman · Angewandte Chemie International Edition · 2007 · 3.1K citations

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Development of Novel Fluorescence Probes That Can Reliably Detect Reactive Oxygen Species and Distinguish Specific Species

Ken‐ichi Setsukinai, Yasuteru Urano, Katsuko Kakinuma et al. · Journal of Biological Chemistry · 2003 · 1.3K citations · Full text

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Macrophage Myeloperoxidase Regulation by Granulocyte Macrophage Colony-Stimulating Factor in Human Atherosclerosis and Implications in Acute Coronary Syndromes

Seigo Sugiyama, Yoshikatsu Okada, Galina K. Sukhova et al. · American Journal Of Pathology · 2001 · 699 citations

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Highly Sensitive Fluorescence Probes for Nitric Oxide Based on Boron Dipyrromethene ChromophoreRational Design of Potentially Useful Bioimaging Fluorescence Probe

Yu Gabe, Yasuteru Urano, Kazuya Kikuchi et al. · Journal of the American Chemical Society · 2004 · 661 citations

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Chlorinative stress: An under appreciated mediator of neurodegeneration?

Yann Wan Yap, Matthew Whiteman, Nam Sang Cheung · Cellular Signalling · 2006 · 570 citations · Full text

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