A Promoter Polymorphism of Neurotrophin 3 Gene Is Associated With Curve Severity and Bracing Effectiveness in Adolescent Idiopathic Scoliosis

Abstract

The NTF3 gene polymorphisms are not associated with the occurrence of AIS, but the promoter polymorphism (rs11063714) is associated with the curve severity, implicating an alleviating role of NTF3 in the curve progression of AIS. In addition, the promoter polymorphism is also associated with brace responsiveness. These findings indicated that NTF3 gene might be a disease-modifying gene of AIS.