Preparation and conformational properties of tetrahydroxy[3.1.3.1]metacyclophanes

Abstract

The preparation of a novel macrocyclic compound, tetrahydroxy[3.1.3.1]metacyclophane 5 by base-catalysed condensation of 1,3-(2,2′-dihydroxy-5,5′-di-tert-butyldiphenyl) propane 4 with formaldehyde in xylene in 90% yield is described and its conformational properties are discussed.