Concepedia

A method for the synthesis of pyridines from aldehydes, alkynes and NH4OAc involving Rh-catalyzed hydroacylation and N-annulation

Yong-Kyun Sim, Hyejeong Lee, Jung‐Woo Park, Dong‐Su Kim, Chul‐Ho Jun

Chemical Communications · 2012 · 45 citations · 29 references

DOI

Concepts

Abstract

A new method for regiocontrolled pyridine synthesis has been developed involving sequential Rh(I)-catalyzed chelation-assisted hydroacylation of alkynes with aldehydes followed by Rh(III)-promoted N-annulation of the resulting α,β-enones with another alkyne and NH(3).

References

29

Metal−Organic Cooperative Catalysis in C−H and C−C Bond Activation and Its Concurrent Recovery

Young Jun Park, Jung‐Woo Park, Chul‐Ho Jun · Accounts of Chemical Research · 2008 · 927 citations

, , +16

Metal-catalyzed direct alkylations of (hetero)arenes via C–H bond cleavages with unactivated alkyl halides

Lutz Ackermann · Chemical Communications · 2010 · 487 citations · Full text

, , +15

An Efficient Low-Temperature Route to Polycyclic Isoquinoline Salt Synthesis via C−H Activation with [Cp*MCl<sub>2</sub>]<sub>2</sub> (M = Rh, Ir)

Ling Li, William W. Brennessel, William D. Jones · Journal of the American Chemical Society · 2008 · 460 citations

, , +15

Isoquinoline Synthesis via Rhodium-Catalyzed Oxidative Cross-Coupling/Cyclization of Aryl Aldimines and Alkynes

Nicolas Guimond, Keith Fagnou · Journal of the American Chemical Society · 2009 · 451 citations

, , +15

Rhodium(III)-Catalyzed Synthesis of Isoquinolines from Aryl Ketone <i>O</i>-Acyloxime Derivatives and Internal Alkynes

Pei Chui Too, Yi‐Feng Wang, Shunsuke Chiba · Organic Letters · 2010 · 429 citations

, , +16