Phosphodiesterase‐4 inhibition improves corticosteroid insensitivity in pulmonary endothelial cells under oxidative stress

Abstract

Combination of rolipram and dexamethasone shows additive properties in HPAECs under glucocorticoid insensitive conditions. These results may be of potential value in future anti-inflammatory therapies using combination of PDE4 inhibitors and glucocorticoids.