An Efficient One-Pot Copper-Catalyzed Approach to Isoquinolin-1(2<i>H</i>)-one Derivatives

Abstract

A simple and efficient copper-catalyzed method for synthesis of 3,4-disubstituted isoquinolin-1(2H)-one derivatives via cascade reactions of substituted 2-halobenzamides with beta-keto esters under mild conditions has been developed, and the method has economical and practical advantages.