Psychopathology, executive (frontal) and general cognitive impairment in relation to duration of initially untreated <i>versus</i> subsequently treated psychosis in chronic schizophrenia

Abstract

Increasing duration of initially untreated psychosis was associated specifically with heightened accrual of prominent negative symptoms and general cognitive impairment. Executive dyscontrol, though also prominent in these patients, may be 'locked-in' at an earlier phase of the illness.