Chemical Communications · 2011 · 60 citations · 17 references
Life SciencesBiotechnologyMolecular BiologyNanobiotechnologyNanotechnologySynthetic BiologyNucleic Acid Drug DesignRna ChemistryRna EngineeringRna InterferenceRna StructureSmall Interfering Rna BiologyNanostructuresRna Interference ConstructsRna JunctionsRna Nanostructure DesignRna NanostructuresSmall Interfering Ribonucleic Acids (Sirnas)Small Interfering Rna DesignSynthetic Small Interfering Ribonucleic Acid Design
Branched RNAs with three- or four-way junctions were designed by assembling single-stranded RNA for RNA interference. Human Dicer transformed branched RNAs into about 20 base pairs of double-stranded RNA, which is a standard siRNA species. Our tetramer design provides a potent silencing effect over a period of 5 days.
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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
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Folding DNA to create nanoscale shapes and patterns
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