A Peptide Dendrimer Model for Vitamin B₁₂ Transport Proteins

Abstract

Dendritic cobalamin ligands: The first dendritic ligands for vitamin B12 were identified from a combinatorial library of peptide dendrimers that feature metal-coordinating residues at the core. Molecular recognition and discrimination among different amino acid sequences revealed dendrimers with a polyanionic shell of glutamates and a coordinating cysteine or histidine at the core that displays favorable binding towards aquocobalamin.