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Two New Fungal Azaphilones from Talaromyces luteus, with Monoamine Oxidase Inhibitory Effect
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1990
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New Fungal AzaphilonesMedicinal ChemistryAzaphilone CompoundsAntifungal AgentBiochemistryAntiparasitic AgentMedicineNatural SciencesMechanism Of ActionMedicinal FungiTalaromyces LuteusMicrobiologyPharmacologyMonoamine OxidasePharmaceutical ChemistryInhibitory ActivityDrug DiscoveryDrug Resistance
Two new compounds with monoamine oxidase (MAO) inhibitory effect isolated from an ascomycete, Talaromyces luteus, have been deduced to be azaphilone compounds, (8R)-7-deacetyl-O 8 ,8-dihydro-7-epi-sclerotiorin and its (Z)-isomer at position 11 from their chemical and spectral data