Determination of four selective serotonin reuptake inhibitors by capillary isotachophoresis

Abstract

We determined an optimal electrolyte system for isotachophoresis (ITP) with conductivity detection of citalopram, fluoxetine, fluvoxamine and sertraline. The analysis conditions were applied to the determination of these selective serotonin re-uptake inhibitors in antidepressant drugs. It is shown that capillary ITP with conductivity detection is a simple and quick method for the determination of citalopram, fluoxetine, fluvoxamine and sertraline in drugs.