T and B Lymphocyte Membrane Markers in Cells from Patients with Leukemia and Lymphoma

Abstract

Rosette formation of human lymphocytes with untreated sheep erythrocytes (E) or sheep erythrocytes treated with antibody and complement (EAC) may be employed as a marker of T and B lymphocytes. Cells from 16 patients with leukemia and from 18 with lymphoma were compared with normal lymphocytes in their ability to form E and EAC rosettes. The results were compared with the <i>in vitro </i>responses to PHA and MLR. A correlation was observed between the impaired responses to PHA and MLR and diminished percentages of cells having receptors for E or both E and EAC.