Publication | Closed Access
Defect Extrinsic to Stem Cells in Spleens of Steel Anemic Mice
48
Citations
0
References
1971
Year
Adult Stem CellImmunologyBlood CellDefect ExtrinsicSteel Anemic MiceBone Marrow FailureW/wv SpleensStem Cell MobilizationHematologyAlternate GenotypesStem CellsCell TransplantationHealth SciencesXenotransplantationW/wv Mouse SpleensCell BiologyMyelopoiesisStem Cell ResearchMedicine
The S1/S1d, +/+ and W/Wv mouse spleens, residing in situ or transplanted into recipient mice of identical or alternate genotypes, were compared with respect to their abilities to support hemopoietic colony formation by exogenous bone marrow cells inoculated intravenously after whole-body x-irradiation. In contrast to the normal numbers of colonies formed consistently in +/+ and W/Wv spleens, few or no colonies were formed in S1/S1d spleens, even when spleens of S1/S1d and W/Wv types resided side-by-side in the same abdominal cavity. These findings strengthen the hypothesis that the anemia of the steel (S1/S1d) mouse results from a defect in its hemopoietic tissue matrix rather than in its hemopoietic stem cells or humoral regulatory apparatus.