New Procedure for One‐Pot Synthesis of 3,4‐Dihydropyrimidin‐2(1 <i>H</i> )‐ones by Biginelli Reaction

Abstract

Abstract A practical green chemistry procedure for synthesis of 3,4‐dihydropyrimidin‐2(1H);‐ones in good yields was successfully carried out in micellar systems according to the Biginelli reaction using β‐ketoester, urea and appropriate aromatic aldehyde in the presence of CuCl2 · H2O as catalyst. The advantages of this method involved the broader application scope of substrates, the more environmental friendly process and the low‐cost of the Lewis acid catalyst.