Matrix Metalloproteinases, Tissue Inhibitor of Matrix Metalloproteinase‐1, and Laminin‐5 γ2 Chain Immunolocalization in Gingival Tissue of Endotoxin‐Induced Periodontitis in Rats: Effects of Low‐Dose Doxycycline and Alendronate

Abstract

Our findings suggest that alendronate and/or doxycycline may inhibit MMP-8 expression significantly; particularly, their combined administration may provide beneficial effects in periodontal treatment. Moreover, individual administration of alendronate and doxycycline results in significant increases in TIMP-1 expression in gingiva. However, these effects of combined low-dose doxycycline and alendronate on MMPs and TIMP should be verified by clinical human trials before these agents are used in dental practice.