<i>E</i><i>scherichia</i><i> coli</i> Glucuronylsynthase: An Engineered Enzyme for the Synthesis of β-Glucuronides

Abstract

The glycosynthase derived from E. coli beta-glucuronidase catalyzes the glucuronylation of a range of primary, secondary, and aryl alcohols with moderate to excellent yields. The procedure provides an efficient, stereoselective, and scalable single-step synthesis of beta-glucuronides under mild conditions.