Publication | Closed Access

The small-molecule tyrosine kinase inhibitor nilotinib is a potent noncompetitive inhibitor of the SN-38 glucuronidation by human UGT1A1

Inhibitory ActivityPotent Noncompetitive InhibitorSignal TransductionNovel TherapySn-38 GlucuronidationG Protein-coupled ReceptorMedicineReceptor Tyrosine KinaseHuman Ugt1a1PharmacologyCell BiologyCell SignalingNitrosative StressDrug Discovery