Publication | Closed Access
Utility of π-acceptors in charge-transfer complexation of alkaloids: chloranilic acid as a spectrophotometric titrant in non-aqueous media
37
Citations
0
References
1981
Year
Organometallic ElectrochemistryOrganic ChemistryCharge-transfer ComplexationChemistrySpectrophotometric TitrantMedicinal ChemistryDrug PurityBioanalysisAnalytical ChemistrySpectrophotometric TitrationClinical ChemistryLiquid ChromatographyChromatographyBiochemistryChromatographic AnalysisPharmacologySpectrophotometric Titration MethodHalogenationChloranilic AcidNatural SciencesMedicinePharmacokineticsEnd-point LocationDrug Analysis
A spectrophotometric titration method is described for the determination of some alkaloids and their dosage forms using 0.005 M chloranilic acid solution in 1,4-dioxan as the titrant. The end-point is determined by measuring the change in absorbance of the sample at 535 nm. Quantitative recoveries with good reproducibility are reported for atropine, emetine, reserpine, strychnine, yohimbine and four dosage forms. The least-squares method for the end-point location in the spectrophotometric titration is also proposed.