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A New Palladium-Catalyzed Intramolecular Cyclization: Synthesis of 1-Aminoindole Derivatives and Functionalization of their Carbocylic Rings
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2000
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EngineeringOrganic ChemistryChemistryOrganometallic CatalysisCross-coupling ReactionBiochemistryCarbocylic RingsCarbocylic RingCatalysisPhenylboronic Acid1-Aminoindole DerivativesAsymmetric CatalysisEnantioselective SynthesisBiomolecular EngineeringSimultaneous CyclizationHeterocyclicAlkene MetathesisNatural SciencesHalogenation
Simultaneous cyclization and functionalization of the carbocylic ring of 1 (X=Cl) take place with amines, azoles, and phenylboronic acid in the presence of Pd catalysts to give 2 (R=amino, azolyl, Ph). Fluoro- and chloroindoles 2 (R=F, Cl) can be isolated in the absence of coupling agents. dba=dibenzylideneacetone. Supporting information for this article is available on the WWW under http://www/wiley-vch.de/home/angewandte/ or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.