Catecholamine-producing cells in the synovial tissue during arthritis: modulation of sympathetic neurotransmitters as new therapeutic target

Phagocyte-derived catecholamines enhance acute inflammatory injury

Michael A. Flierl, Daniel Rittirsch, Brian A. Nadeau et al. · Nature · 2007 · 471 citations · Full text

Life Sciences, Immunology, Physiology +14

Release of tumor necrosis factor-alpha from macrophages. Enhancement and suppression are dose-dependently regulated by prostaglandin E2 and cyclic nucleotides.

Harald Renz, Jun Gong, A. Schmidt et al. · The Journal of Immunology · 1988 · 397 citations · Full text

Life Sciences, Immunology, Pharmacology +17

Discovery of endogenous catecholamines in lymphocytes and evidence for catecholamine regulation of lymphocyte function via an autocrine loop.

Jonas Bergquist, A Tarkowski, Rolf Ekman et al. · Proceedings of the National Academy of Sciences · 1994 · 371 citations · Full text

Life Sciences, Biochemistry, Immunology +17

Human CD4+CD25+ regulatory T cells selectively express tyrosine hydroxylase and contain endogenous catecholamines subserving an autocrine/paracrine inhibitory functional loop

Marco Cosentino, A. Fietta, Marco Ferrari et al. · Blood · 2006 · 320 citations · Full text

Life Sciences, Endocrinology, Immunology +17

The loss of sympathetic nerve fibers in the synovial tissue of patients with rheumatoid arthritis is accompanied by increased norepinephrine release from synovial macrophages

Luitpold E. Miller, Hans‐Peter Jüsten, Jürgen Schcölmerich et al. · The FASEB Journal · 2000 · 292 citations

Medicine, Immunology, Physiology +16