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Amino acid substitutions far from the active site of bacteriophage T4 lysozyme reduce catalytic activity and suggest that the C-terminal Lobe of the enzyme participates in substrate binding

BiochemistryProtein FoldingMedicineEnzyme CatalysisBacteriophageActive SiteAmino Acid SubstitutionsStructure-function Enzyme KineticsMicrobiologyPhage BiologyBacteriophage T4 Lysozyme