Dysregulation of CD28 and CTLA‐4 expression by CD4 T cells from previously immunodeficient HIV‐infected patients with sustained virological responses to highly active antiretroviral therapy

Abstract

Expression of CD28, CTLA-4 and perforin by CD4 lymphocytes remain dysregulated in HIV-infected patients with previous severe immunodeficiency, despite increased CD4 T-cell counts and control of HIV viraemia by HAART.