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The Regional Distribution of Somatostatin in the Rat Brain
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1975
Year
NeurotransmitterRat BrainPituitary GlandRegional DistributionNeuroendocrine MechanismHypothalamic PeptideNeurochemistryHealth SciencesEndocrine MechanismNeuropharmacologyNervous SystemEndocrinologyPharmacologyNeurophysiologyNeuroanatomyPhysiologyNeuroendocrine DisorderNeuroscienceCentral Nervous SystemMedicineSpecific Radioimmunoassay
A sensitive and specific radioimmunoassay for somatostatin (SRIF) has been used to determine the regional distribution of SRIF in rat brain. The hypothalamus contained the highest concentration of SRIF. Lower, but significant amounts of SRIF were present outside of the hypothalalmus. Within the hypothalamus, the concentration of SRIF was highest in the median eminence and arcuate nucleus although all of the hypothalmic nuclei contained some fo this material. The implications of this distribution are discussed.