Reversal of Morphine Anesthesia with Naloxone

Abstract

Six hours after intravenous injection of morphine, 2 mg/kg, seven healthy adults received a ten-hour intravenous infusion of naloxone (3.66 μg/kg loading dose plus 3.66 μg/kg/hr), totaling 40 μg/kg. Immediately before administration of naloxone, resting minute ventilation (E) was 6.2 ± 0.4 (SE) l/mi