Drug absorption through the skin: a mixed blessing.

Abstract

Drug absorption through the skin: a mixed blessing Skin is a barrier that keeps body water in and micro- organisms and noxious chemicals out. Topical drugs, the mainstay of treatment in dermatology, are applied in the hope and expectation that any percutaneous absorption will be minimal and that systemic side effects will not occur. It is becoming apparent though that skin is not quite as impermeable as often believed. Undoubtedly, drugs can be absorbed through the skin and produce either unwanted or intended systemic effects.